(E)-Flavokawain A

• CAT Number: I018420
• CAS Number: 37951-13-6
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.33
• Purity: ≥95%
• Target: Apoptosis
• Storage: 4°C, protect from light
• IUPAC Name: (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+
• InChIKey: CGIBCVBDFUTMPT-RMKNXTFCSA-N
• SMILES: COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O

(E)-Flavokawain A (Cat No.:I018420) is a bioactive chalcone derivative found in the roots of Kava (Piper methysticum). It has garnered attention for its potential therapeutic properties, including anti-inflammatory, antioxidant, and anticancer effects. Research suggests that (E)-Flavokawain A may inhibit tumor cell proliferation and induce apoptosis in cancer cells, particularly in melanoma and breast cancer. Additionally, it may help protect against oxidative stress, promoting overall cellular health. Studies continue to explore its pharmacological potential for therapeutic applications.

Reference

[1]. Zi X, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65(8):3479-86.