(E)-10-Hydroxynortriptyline

• CAT Number: I044298
• CAS Number: 47132-16-1
• Molecular Formula: C19H21NO
• Molecular Weight: 279.38
• Purity: ≥95%
• Synonyms: (2E)-2-[3-(methylamino)propylidene]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-9-ol
• InChI: InChI=1S/C19H21NO/c1-20-12-6-11-16-15-8-3-2-7-14(15)13-19(21)18-10-5-4-9-17(16)18/h2-5,7-11,19-21H,6,12-13H2,1H3/b16-11+
• InChIKey: VAGXZGJKNUNLHK-LFIBNONCSA-N
• SMILES: CNCC/C=C/1\C2=CC=CC=C2CC(C3=CC=CC=C31)O

(E)-10-Hydroxynortriptyline（Cat No.:I044298）is an active metabolite of nortriptyline, a tricyclic antidepressant (TCA) used to treat depression and certain chronic pain conditions. This compound results from hydroxylation at the 10th position of the nortriptyline molecule and exists in the (E)-isomeric form, which can influence its pharmacokinetics and receptor binding profile. (E)-10-Hydroxynortriptyline retains affinity for norepinephrine and serotonin transporters, contributing to the therapeutic effects and side effect profile of its parent drug. It is studied in clinical pharmacology to understand drug metabolism, efficacy, and individualized treatment responses based on metabolic variations.