DYRK1-IN-1

• CAT Number: I045380
• CAS Number: 2814486-79-6
• Molecular Formula: C12H12N6
• Molecular Weight: 240.26
• Purity: ≥95%
• Synonyms: N,N-dimethyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
• InChI: InChI=1S/C12H12N6/c1-17(2)12-13-7-5-10(16-12)9-8-15-18-11(9)4-3-6-14-18/h3-8H,1-2H3
• InChIKey: IFLBFWBMAWIBBZ-UHFFFAOYSA-N
• SMILES: CN(C)C1=NC=CC(=N1)C2=C3C=CC=NN3N=C2

DYRK1-IN-1 (Cat No.: I045380) is a potent and selective inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), a kinase involved in neuronal development, synaptic plasticity, and cell cycle regulation. Overexpression or dysregulation of DYRK1A has been implicated in neurodegenerative diseases, such as Alzheimer’s disease, and genetic disorders like Down syndrome. DYRK1-IN-1 is widely used in preclinical research to study the biological functions of DYRK1A and to explore its potential as a therapeutic target for neurological and cognitive disorders associated with kinase dysregulation.

Reference

[1]. Henderson SH, et al. Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. J Med Chem. 2021;64(15):11709-11728.
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