Dynorphin A (1-8)

• CAT Number: I026623
• CAS Number: 75790-53-3
• Molecular Formula: C46H72N14O10
• Molecular Weight: 981.15
• Purity: ≥95%
• Synonyms: (2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoic acid
• IUPAC Name: (2S,3S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoic acid
• InChI: InChI=1S/C46H72N14O10/c1-5-27(4)38(44(69)70)60-41(66)33(14-10-20-53-46(50)51)57-40(65)32(13-9-19-52-45(48)49)58-42(67)34(21-26(2)3)59-43(68)35(23-28-11-7-6-8-12-28)56-37(63)25-54-36(62)24-55-39(64)31(47)22-29-15-17-30(61)18-16-29/h6-8,11-12,15-18,26-27,31-35,38,61H,5,9-10,13-14,19-25,47H2,1-4H3,(H,54,62)(H,55,64)(H,56,63)(H,57,65)(H,58,67)(H,59,68)(H,60,66)(H,69,70)(H4,48,49,52)(H4,50,51,53)/t27-,31-,32-,33?,34-,35-,38-/m0/s1
• InChIKey: WRPLGMBDXVBPEG-ZFBBIHQWSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N

Dynorphin A (1–8)（Cat No.:I026623）is an endogenous opioid peptide consisting of the first eight amino acids of the full-length dynorphin A. It acts primarily on kappa-opioid receptors (KORs), playing a key role in modulating pain perception, stress response, emotional regulation, and neuroendocrine function. This shorter fragment retains potent analgesic and neuromodulatory activity, making it valuable for studying opioid receptor selectivity and signaling mechanisms. Dynorphin A (1–8) is widely used in neuroscience and pharmacological research to explore opioid system dynamics, develop novel analgesics, and investigate its involvement in mood disorders and addiction.