DY268

• CAT Number: R032751
• CAS Number: 1609564-75-1
• Molecular Formula: C30H32N4O5S
• Molecular Weight: 560.66
• Purity: ≥95%
• Synonyms: 1-[(3-methoxyphenyl)methyl]-N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-3-(4-methylphenyl)pyrazole-4-carboxamide
• InChI: InChI=1S/C30H32N4O5S/c1-21-7-10-24(11-8-21)29-27(20-33(32-29)19-23-5-4-6-26(17-23)38-3)30(35)31-25-12-9-22(2)28(18-25)40(36,37)34-13-15-39-16-14-34/h4-12,17-18,20H,13-16,19H2,1-3H3,(H,31,35)
• InChIKey: KQSPAAPFKIEUGH-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C2=NN(C=C2C(=O)NC3=CC(=C(C=C3)C)S(=O)(=O)N4CCOCC4)CC5=CC(=CC=C5)OC

DY268 (Cat No.: R032751) is a synthetic small-molecule compound investigated as a research probe for studying cellular signaling and disease-related mechanisms. While its precise pharmacological targets remain under characterization, DY268 is applied in preclinical studies to evaluate structure–activity relationships, target engagement, and potential biological effects. Researchers use it to explore pathways linked to cancer, metabolic regulation, or inflammatory processes. Though not intended for therapeutic use, DY268 serves as a useful experimental tool to advance understanding of molecular biology and to support drug discovery research.

Reference

[1]. Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.
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[2]. Kyounghwa Jung, et al. Farnesoid X Receptor Activation Impairs Liver Progenitor Cell-Mediated Liver Regeneration via the PTEN-PI3K-AKT-mTOR Axis in Zebrafish. Hepatology. 2021 Jul;74(1):397-410.
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[3]. Leah M Norona, et al. In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk. Arch Toxicol. 2020 Sep;94(9):3185-3200.
[Content Brief]