For research use only. Not for therapeutic Use.
DuP-697(CAT: I006557) is a potent, selective, and orally active cyclooxygenase-2 (COX-2) inhibitor belonging to the vicinal diaryl heterocycle class. It irreversibly inhibits COX-2 with an IC₅₀ of 10 nM, showing strong selectivity over COX-1 (IC₅₀ = 800 nM). In HT29 colorectal cancer cells, DuP-697 suppresses proliferation (IC₅₀ = 42.8 nM), induces concentration-dependent apoptosis, and exerts antiangiogenic activity. It blocks prostaglandin synthesis, conferring anti-inflammatory, anticancer, and antipyretic effects. In vivo, DuP-697 demonstrates potent activity in arthritis and fever models without impairing renal blood flow. These properties establish DuP-697 as a valuable tool for cancer, inflammation, and prostaglandin research.
| CAS Number | 88149-94-4 |
| Synonyms | 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene |
| Molecular Formula | C17H12BrFO2S2 |
| Purity | ≥95% |
| IUPAC Name | 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene |
| InChI | InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3 |
| InChIKey | AJFTZWGGHJXZOB-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=C(SC(=C2)Br)C3=CC=C(C=C3)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
