For research use only. Not for therapeutic Use.
Duostatin 5（Cat No.:I044161）is a synthetic cytotoxic agent derived from auristatin, designed for use in antibody-drug conjugates (ADCs) targeting cancer cells. It functions as a potent tubulin polymerization inhibitor, disrupting microtubule dynamics, arresting the cell cycle at the G2/M phase, and inducing apoptosis. Duostatin 5 is typically linked to monoclonal antibodies via cleavable or non-cleavable linkers, enabling selective delivery to tumor cells while minimizing systemic toxicity. Its high potency makes it suitable for targeting low-abundance antigens in solid and hematologic malignancies, supporting the development of precision oncology therapeutics.
| CAS Number | 2124210-34-8 |
| Synonyms | (2S)-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(2S)-1-(4-aminophenyl)-3-azidopropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N,3-dimethylbutanamide |
| Molecular Formula | C40H69N9O6 |
| Purity | ≥95% |
| IUPAC Name | (2S)-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(2S)-1-(4-aminophenyl)-3-azidopropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N,3-dimethylbutanamide |
| InChI | InChI=1S/C40H69N9O6/c1-13-26(6)36(48(10)40(53)34(24(2)3)45-39(52)35(25(4)5)47(8)9)32(54-11)22-33(50)49-20-14-15-31(49)37(55-12)27(7)38(51)44-30(23-43-46-42)21-28-16-18-29(41)19-17-28/h16-19,24-27,30-32,34-37H,13-15,20-23,41H2,1-12H3,(H,44,51)(H,45,52)/t26-,27+,30-,31-,32+,34-,35-,36-,37+/m0/s1 |
| InChIKey | QIHHTRNUHMRKQK-MNFMTBGBSA-N |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=C(C=C2)N)CN=[N+]=[N-])OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
