Duloxetine

• CAT Number: I000594
• CAS Number: 116539-59-4
• Molecular Formula: C18H19NOS
• Molecular Weight: 297.41
• Purity: ≥95%
• Storage: 2 years -20°C liquid
• IUPAC Name: (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
• InChI: InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
• InChIKey: ZEUITGRIYCTCEM-KRWDZBQOSA-N
• SMILES: CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32

Duloxetine（Cat No.:I000594）is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It works by increasing levels of serotonin and norepinephrine in the brain, helping regulate mood and pain perception. Chemically, it is a thiochromane derivative with the molecular formula C₁₈H₁₉NOS. Duloxetine is typically administered as the hydrochloride salt in capsule form. Common side effects include nausea, dry mouth, dizziness, and fatigue. It should be used cautiously in patients with liver or kidney impairment and may interact with other serotonergic medications.

Reference

[1] Knadler MP, et al. Clin Pharmacokinet. 2011, 50(5):281-94.