For research use only. Not for therapeutic Use.
DSR-6434(CAT: I010678) is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50 values of 7.2 nM (human TLR7) and 4.6 nM (mouse TLR7). In NF-κB reporter assays, DSR-6434 specifically activates TLR7 without cross-reactivity to the structurally related TLR8 or TLR9, confirming its receptor selectivity. In vivo, intravenous administration (0.1–1 mg/kg, biweekly, 4 weeks) produces strong antitumor effects, significantly suppressing lung metastasis in B6C3F1 mice, including complete inhibition at 1 mg/kg. With its potent immune-activating and tumor-suppressive properties, DSR-6434 is a valuable research tool for cancer immunotherapy, innate immune signaling, and TLR-targeted drug discovery.
| CAS Number | 1059070-10-8 |
| Synonyms | 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one |
| Molecular Formula | C19H28N8O2 |
| Purity | ≥95% |
| IUPAC Name | 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one |
| InChI | InChI=1S/C19H28N8O2/c1-4-5-8-21-18-24-16(20)15-17(25-18)27(19(28)23-15)12-13-6-7-14(22-11-13)29-10-9-26(2)3/h6-7,11H,4-5,8-10,12H2,1-3H3,(H,23,28)(H3,20,21,24,25) |
| InChIKey | SSZHESNDOMBSRV-UHFFFAOYSA-N |
| SMILES | CCCCNC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CN=C(C=C3)OCCN(C)C)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
