For research use only. Not for therapeutic Use.
DSPE-Thiol (Cat No.: I042509) is a thiol-functionalized phospholipid designed for incorporation into liposomes, micelles, and other lipid-based nanocarriers. The DSPE tail enables stable integration into lipid bilayers, while the free thiol (-SH) group allows for site-specific conjugation with maleimide- or gold-functionalized compounds via thiol-reactive chemistry. DSPE-Thiol is widely used in targeted drug delivery, surface modification, and biosensor development. Its reactive functionality makes it ideal for attaching ligands, antibodies, or imaging agents to lipid nanoparticles in biomedical and pharmaceutical applications.
| CAS Number | 144735-82-0 |
| Synonyms | [(2R)-3-[hydroxy-[2-(3-sulfanylpropanoylamino)ethoxy]phosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate |
| Molecular Formula | C44H86NO9PS |
| Purity | ≥95% |
| InChI | InChI=1S/C44H86NO9PS/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-43(47)51-39-41(40-53-55(49,50)52-37-36-45-42(46)35-38-56)54-44(48)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h41,56H,3-40H2,1-2H3,(H,45,46)(H,49,50)/t41-/m1/s1 |
| InChIKey | VPGMYYHJMRLITI-VQJSHJPSSA-N |
| SMILES | CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)CCS)OC(=O)CCCCCCCCCCCCCCCCC |
| Reference | [1]. Sharon M, et al. Nearest-neighbor recognition in phospholipid membranes: a molecular-level approach to the study of membrane suprastructure. J. Am. Chem. Soc. 1992, 114, 25, 9828-9835. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
