DSPE-NHS

• CAT Number: I042507
• CAS Number: 1383932-86-2
• Molecular Formula: C49H89N2O13P
• Molecular Weight: 945.21
• Purity: ≥95%
• Synonyms: [(2R)-3-[2-[[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]amino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate
• InChI: InChI=1S/C49H89N2O13P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-47(55)60-41-43(63-48(56)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)42-62-65(58,59)61-40-39-50-44(52)35-38-49(57)64-51-45(53)36-37-46(51)54/h43H,3-42H2,1-2H3,(H,50,52)(H,58,59)/t43-/m1/s1
• InChIKey: WTEHXKGZZJYCSX-VZUYHUTRSA-N
• SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)CCC(=O)ON1C(=O)CCC1=O)OC(=O)CCCCCCCCCCCCCCCCC

DSPE-NHS (Cat No.: I042507) is a reactive phospholipid derivative used for bioconjugation. The NHS ester reacts efficiently with primary amines on proteins, peptides, or other biomolecules to form stable amide bonds. The DSPE tail allows integration into liposomes or lipid-based nanocarriers, enabling surface functionalization for targeted drug delivery, imaging, or vaccine development. DSPE-NHS is widely applied in the creation of antibody-labeled nanoparticles, PEGylated liposomes, and other functional lipid systems in pharmaceutical and biomedical research requiring precise ligand attachment.

Reference

[1]. Mikio Tatsutomi, et al. Preparation of a nitric oxide imaging agent from gelatin derivative micelles. Regen Ther. 2016 Sep 14;5:64-71.
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