For research use only. Not for therapeutic Use.
DSPE-Mal (Cat No.: I042508) is a lipid derivative featuring a maleimide functional group that enables site-specific conjugation to thiol-containing molecules via stable thioether bonds. Incorporated into liposomes or micelles, DSPE-Mal facilitates the attachment of peptides, antibodies, or polymers for targeted drug delivery and imaging applications. The hydrophobic DSPE tail anchors into lipid bilayers, while the reactive maleimide group remains exposed for bioconjugation. DSPE-Mal is widely used in nanomedicine, vaccine development, and surface functionalization for creating precision therapeutic and diagnostic platforms.
| CAS Number | 1360858-99-6 |
| Synonyms | [(2R)-3-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate |
| Molecular Formula | C48H87N2O11P |
| Purity | ≥95% |
| InChI | InChI=1S/C48H87N2O11P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-47(54)58-41-43(61-48(55)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)42-60-62(56,57)59-40-38-49-44(51)37-39-50-45(52)35-36-46(50)53/h35-36,43H,3-34,37-42H2,1-2H3,(H,49,51)(H,56,57)/t43-/m1/s1 |
| InChIKey | DOLZZPOFNKNXOL-VZUYHUTRSA-N |
| SMILES | CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)CCN1C(=O)C=CC1=O)OC(=O)CCCCCCCCCCCCCCCCC |
| Reference | [1]. Anu Puri, et al. HER2-specific affibody-conjugated thermosensitive liposomes (Affisomes) for improved delivery of anticancer agents. J Liposome Res. 2008;18(4):293-307. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
