DSM705 hydrochloride（Cat No.:I044174）is a small-molecule inhibitor that selectively targets SIRT5, a mitochondrial NAD⁺-dependent lysine deacylase involved in regulating cellular metabolism and oxidative stress. By inhibiting SIRT5, DSM705 affects the desuccinylation, demalonylation, and deglutarylation of metabolic enzymes, leading to altered mitochondrial function and metabolic reprogramming. It has been explored in the context of cancer metabolism, neurodegeneration, and other diseases associated with mitochondrial dysfunction. DSM705 hydrochloride is commonly used in research to elucidate SIRT5’s role in post-translational modification and to evaluate its potential as a therapeutic target.