DS44960156

• CAT Number: I045435
• CAS Number: 2361327-08-2
• Molecular Formula: C20H15NO5
• Molecular Weight: 349.34
• Purity: ≥95%
• Synonyms: 4-(5-oxo-2,4-dihydro-1H-chromeno[3,4-c]pyridine-3-carbonyl)benzoic acid
• InChI: InChI=1S/C20H15NO5/c22-18(12-5-7-13(8-6-12)19(23)24)21-10-9-14-15-3-1-2-4-17(15)26-20(25)16(14)11-21/h1-8H,9-11H2,(H,23,24)
• InChIKey: OXUKTNZACAKVRG-UHFFFAOYSA-N
• SMILES: C1CN(CC2=C1C3=CC=CC=C3OC2=O)C(=O)C4=CC=C(C=C4)C(=O)O

DS44960156 (Cat No.: I045435) is a potent, selective small-molecule inhibitor of interleukin-36 receptor (IL-36R), a key mediator in the IL-1 cytokine family involved in skin inflammation and immune regulation. By blocking IL-36R signaling, it suppresses downstream pro-inflammatory pathways, including NF-κB and MAPK activation, reducing cytokine and chemokine production. DS44960156 is primarily investigated for the treatment of inflammatory skin disorders such as generalized pustular psoriasis (GPP) and other IL-36–driven diseases, offering a targeted therapeutic approach with potential to improve efficacy and reduce systemic side effects.

Reference

[1]. Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898.
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