For research use only. Not for therapeutic Use.
DS21150768(CAT: I040268) is a potent, orally bioavailable inhibitor of hematopoietic progenitor kinase 1 (HPK1), a negative regulator of T-cell receptor signaling. By selectively targeting HPK1, DS21150768 enhances T-cell activation and function, positioning it as a promising immunomodulatory agent in cancer immunotherapy. Preclinical studies demonstrate its capacity to stimulate immune responses and exert anticancer effects, making it a valuable tool for studying T-cell–mediated tumor suppression. With its strong pharmacological profile, DS21150768 supports research into immune checkpoint regulation, tumor microenvironment remodeling, and the development of novel cancer treatment strategies involving immune system modulation.
| Synonyms | N-[4-[2-amino-5-(2,6-dimethylpyridin-4-yl)pyridin-3-yl]phenyl]-4-[(3-fluoro-1-bicyclo[1.1.1]pentanyl)methylamino]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide |
| Molecular Formula | C36H32F2N6O2 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[2-amino-5-(2,6-dimethylpyridin-4-yl)pyridin-3-yl]phenyl]-4-[(3-fluoro-1-bicyclo[1.1.1]pentanyl)methylamino]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide |
| InChI | InChI=1S/C36H32F2N6O2/c1-21-13-24(14-22(2)42-21)25-15-29(32(39)40-16-25)23-3-7-27(8-4-23)43-33(45)31-30(41-20-35-17-36(38,18-35)19-35)11-12-44(34(31)46)28-9-5-26(37)6-10-28/h3-16,41H,17-20H2,1-2H3,(H2,39,40)(H,43,45) |
| InChIKey | UAUOPQIZEQRXRH-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=N1)C)C2=CC(=C(N=C2)N)C3=CC=C(C=C3)NC(=O)C4=C(C=CN(C4=O)C5=CC=C(C=C5)F)NCC67CC(C6)(C7)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
