For research use only. Not for therapeutic Use.
DS-1971a（Cat No.:I015141）is a potent, selective small-molecule antagonist of the NaV1.7 voltage-gated sodium channel, a key mediator of pain signal transmission in peripheral neurons. By blocking NaV1.7, DS-1971a reduces neuronal excitability and has shown significant analgesic effects in preclinical and clinical studies. It is widely studied as a promising non-opioid therapeutic candidate for chronic pain conditions, including neuropathic pain. With high selectivity and favorable pharmacological properties, DS-1971a serves as an important research tool in neuroscience, pain biology, and the development of novel analgesic strategies.
| CAS Number | 1450595-86-4 |
| Synonyms | 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide |
| Molecular Formula | C20H21ClFN5O3S |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide |
| InChI | InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1 |
| InChIKey | OJKONCJPCULNOW-DYVFJYSZSA-N |
| SMILES | CN1C(=CC=N1)[C@H]2CCCC[C@@H]2OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=NC=C4)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
