DS-1205b free base

For research use only. Not for therapeutic Use.

  • CAT Number: I026539
  • CAS Number: 1855860-24-0
  • Molecular Formula: C41H42FN5O7
  • Molecular Weight: 735.80
  • Purity: ≥95%
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DS-1205b free base (Cat No.: I026539) is a selective small-molecule inhibitor of the AXL receptor tyrosine kinase, a key regulator of tumor progression, metastasis, and resistance to targeted therapies. By blocking AXL signaling, DS-1205b suppresses downstream pathways such as PI3K/AKT and MAPK, enhancing sensitivity to EGFR inhibitors and other anticancer agents. It has been investigated in preclinical and clinical studies for non-small cell lung cancer and other malignancies. DS-1205b free base is a valuable tool for oncology research and therapeutic development.


CAS Number 1855860-24-0
Synonyms

N-[4-[2-amino-5-[4-[[(2R)-1,4-dioxan-2-yl]methoxy]-3-methoxyphenyl]pyridin-3-yl]-3-fluorophenyl]-5-(5-methylpyridin-2-yl)-1-(oxan-4-ylmethyl)-4-oxopyridine-3-carboxamide

Molecular Formula C41H42FN5O7
Purity ≥95%
InChI InChI=1S/C41H42FN5O7/c1-25-3-7-36(44-18-25)33-21-47(20-26-9-11-51-12-10-26)22-34(39(33)48)41(49)46-29-5-6-31(35(42)17-29)32-15-28(19-45-40(32)43)27-4-8-37(38(16-27)50-2)54-24-30-23-52-13-14-53-30/h3-8,15-19,21-22,26,30H,9-14,20,23-24H2,1-2H3,(H2,43,45)(H,46,49)/t30-/m1/s1
InChIKey ZOEILZXFYPPMTR-SSEXGKCCSA-N
SMILES CC1=CN=C(C=C1)C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)C4=C(N=CC(=C4)C5=CC(=C(C=C5)OCC6COCCO6)OC)N)F)CC7CCOCC7
Reference

[1]. Jimbo T, et, al. DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model. Oncotarget. 2019 Aug 27;10(50):5152-5167.
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