DREADD agonist 21 dihydrochloride

• CAT Number: I045900
• CAS Number: 2250025-92-2
• Molecular Formula: C17H20Cl2N4
• Molecular Weight: 351.27
• Purity: ≥95%
• Synonyms: 6-piperazin-1-yl-11H-benzo[b][1,4]benzodiazepine;dihydrochloride
• InChI: InChI=1S/C17H18N4.2ClH/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14;;/h1-8,18-19H,9-12H2;2*1H
• InChIKey: SETCOPAXYQJWKI-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C2=NC3=CC=CC=C3NC4=CC=CC=C42.Cl.Cl

DREADD agonist 21 dihydrochloride（Cat No.:I045900）is a selective, high-potency ligand for engineered muscarinic receptors used in chemogenetics, known as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). Unlike clozapine-N-oxide (CNO), it shows minimal conversion to clozapine, offering improved specificity and reduced off-target effects. By activating excitatory or inhibitory DREADDs, it enables precise, reversible control of neuronal signaling, behavior, and physiological processes. The dihydrochloride salt form enhances solubility and stability. DREADD agonist 21 is widely used in neuroscience for dissecting neural circuits and therapeutic mechanism studies.