DQP-1105

• CAT Number: R041508
• CAS Number: 380560-89-4
• Molecular Formula: C29H24BrN3O4
• Molecular Weight: 558.42
• Purity: ≥95%
• Synonyms: 4-[3-(4-bromophenyl)-5-(6-methyl-2-oxo-4-phenyl-1H-quinolin-3-yl)-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid
• InChI: InChI=1S/C29H24BrN3O4/c1-17-7-12-22-21(15-17)27(19-5-3-2-4-6-19)28(29(37)31-22)23-16-24(18-8-10-20(30)11-9-18)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
• InChIKey: MVYNQMRZRULRIE-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1)NC(=O)C(=C2C3=CC=CC=C3)C4=NN(C(C4)C5=CC=C(C=C5)Br)C(=O)CCC(=O)O

DQP-1105（Cat No.:R041508）is a selective negative allosteric modulator of GluN2C- and GluN2D-containing NMDA (N-methyl-D-aspartate) receptors, which are ionotropic glutamate receptors involved in synaptic transmission, plasticity, and neurodevelopment. By selectively inhibiting these receptor subtypes, DQP-1105 reduces NMDA receptor-mediated calcium influx without affecting GluN2A or GluN2B subtypes, offering subtype-specific modulation. It is widely used in neuroscience research to investigate the physiological and pathological roles of GluN2C/D in learning, memory, and neurodegenerative diseases. DQP-1105 provides a valuable tool for dissecting NMDA receptor subtype function and for exploring targeted treatments for CNS disorders.