For research use only. Not for therapeutic Use.
DPTIP (Cat No.: I026509) is a potent, selective inhibitor of soluble epoxide hydrolase (sEH), an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have anti-inflammatory, vasodilatory, and cardioprotective effects. By blocking sEH, DPTIP increases EET levels, thereby enhancing their beneficial biological activities. It is used in cardiovascular, inflammatory, and neurological research to study the role of EETs in disease modulation. DPTIP has potential therapeutic applications in hypertension, ischemia-reperfusion injury, pain management, and metabolic disorders, making it a valuable tool for drug discovery and biochemical studies.
| CAS Number | 351353-48-5 |
| Synonyms | 2,6-dimethoxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol |
| Molecular Formula | C21H18N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H18N2O3S/c1-25-15-11-14(12-16(26-2)20(15)24)21-22-18(13-7-4-3-5-8-13)19(23-21)17-9-6-10-27-17/h3-12,24H,1-2H3,(H,22,23) |
| InChIKey | JMXVHYPSBANVAQ-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1O)OC)C2=NC(=C(N2)C3=CC=CS3)C4=CC=CC=C4 |
| Reference | [1]. Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
