For research use only. Not for therapeutic Use.
DPM-1001 trihydrochloride (Cat No.: I045530) is a potent and selective small-molecule inhibitor of copper metabolism MURR1 domain (COMMD1)-dependent pathways, investigated as a therapeutic candidate for Wilson’s disease, a genetic disorder of copper overload. By binding copper ions, it reduces toxic copper accumulation in tissues such as the liver and brain, offering an alternative to traditional chelators like penicillamine. Its trihydrochloride salt form enhances solubility and stability for research and preclinical use. DPM-1001 highlights the promise of targeted copper-binding strategies in metabolic disease therapy.
| Synonyms | methyl (4R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-[4-(pyridin-2-ylmethylamino)butylamino]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;trihydrochloride |
| Molecular Formula | C35H60Cl3N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C35H57N3O3.3ClH/c1-24(10-13-32(40)41-4)28-11-12-29-33-30(15-17-35(28,29)3)34(2)16-14-26(21-25(34)22-31(33)39)37-20-8-7-18-36-23-27-9-5-6-19-38-27;;;/h5-6,9,19,24-26,28-31,33,36-37,39H,7-8,10-18,20-23H2,1-4H3;3*1H/t24-,25-,26-,28-,29+,30+,31-,33+,34+,35-;;;/m1.../s1 |
| InChIKey | VMETYCIJFJYNQW-NIETXTDOSA-N |
| SMILES | CC(CCC(=O)OC)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)NCCCCNCC5=CC=CC=N5)C)O)C.Cl.Cl.Cl |
| Reference | [1]. Krishnan N, et al. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
