DPA-714

• CAT Number: R072249
• CAS Number: 958233-07-3
• Molecular Formula: C22H27FN4O2
• Molecular Weight: 398.47
• Purity: ≥95%
• Synonyms: N,N-Diethyl-2-(2-(4-(2-fluoro-1-ethoxy)phenyl)- 5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide
• IUPAC Name: N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide
• InChI: InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3
• InChIKey: FLZZFWBNYJNHMY-UHFFFAOYSA-N
• SMILES: CCN(CC)C(=O)CC1=C2N=C(C=C(N2N=C1C3=CC=C(C=C3)OCCF)C)C

DPA-714 (CAS 958233-07-3) is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications.It is also a PET tracer binding the TSPO receptor and highly expressed in myeloid cells.

Reference

1.Verweij, Simone L., et al. "Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18 F-DPA-714 PET/CT." European journal of nuclear medicine and molecular imaging 45.11 (2018): 1956-1963.
2.Tan, Chengbo, et al. "[18 F] DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia." EJNMMI research 8.1 (2018): 1-10.
3.Saba, Wadad, et al. "Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F‐DPA‐714." Addiction biology 23.5 (2018): 1000-1009.