DPA-714

  • CAT Number: R072249
  • CAS Number: 958233-07-3
  • Molecular Formula: C22H27FN4O2
  • Molecular Weight: 398.47
  • Purity: ≥95%
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DPA-714 (CAS 958233-07-3) is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications.It is also a PET tracer binding the TSPO receptor and highly expressed in myeloid cells.

Catalog Number R072249
CAS Number 958233-07-3
Synonyms

N,N-Diethyl-2-(2-(4-(2-fluoro-1-ethoxy)phenyl)- 5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

Molecular Formula

C22H27FN4O2

Purity 95%
IUPAC Name N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide
InChI InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3
InChIKey FLZZFWBNYJNHMY-UHFFFAOYSA-N
SMILES CCN(CC)C(=O)CC1=C2N=C(C=C(N2N=C1C3=CC=C(C=C3)OCCF)C)C
Reference

<p>
<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.Verweij, Simone L., et al. &quot;Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18 F-DPA-714 PET/CT.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>European journal of nuclear medicine and molecular imaging</i>&nbsp;45.11 (2018): 1956-1963.<br />
2.Tan, Chengbo, et al. &quot;[18 F] DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>EJNMMI research</i>&nbsp;8.1 (2018): 1-10.<br />
3.Saba, Wadad, et al. &quot;Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F‐DPA‐714.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Addiction biology</i>&nbsp;23.5 (2018): 1000-1009.</span></span></span></p>

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