Doxylamine N’-Oxide

• CAT Number: R014340
• CAS Number: 99430-77-0
• Molecular Formula: C17H22N2O2
• Molecular Weight: 286.38
• Purity: ≥95%
• Synonyms: N,​N-Dimethyl-​2-​[1-​(1-​oxido-​2-​pyridinyl)​-​1-​phenylethoxy]​-ethanamine; N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-ethanamine N2-Oxide
• Storage: Store at RT
• IUPAC Name: N,N-dimethyl-2-[1-(1-oxidopyridin-1-ium-2-yl)-1-phenylethoxy]ethanamine
• InChI: InChI=1S/C17H22N2O2/c1-17(21-14-13-18(2)3,15-9-5-4-6-10-15)16-11-7-8-12-19(16)20/h4-12H,13-14H2,1-3H3
• InChIKey: MDIHSMRZIRBUPR-UHFFFAOYSA-N
• SMILES: CC(C1=CC=CC=C1)(C2=CC=CC=[N+]2[O-])OCCN(C)C

Doxylamine N’-oxide (Cat No.: R014340) is a metabolite of doxylamine, a first-generation antihistamine commonly used as a sleep aid and in allergy relief. The N’-oxide functional group results from oxidative metabolism of the tertiary amine, potentially altering its pharmacokinetic and pharmacodynamic properties. While it retains structural similarity to the parent compound, N’-oxide metabolites often show reduced activity and increased polarity, enhancing water solubility and excretion. Doxylamine N’-oxide is typically studied in drug metabolism research to understand the biotransformation and clearance of doxylamine.