DOTA-PEG5-C6-DBCO

• CAT Number: I026466
• Molecular Formula: C49H71N7O14
• Molecular Weight: 982.13
• Purity: ≥95%
• Synonyms: 2-[4-[2-[2-[2-[2-[2-[2-[2-[[6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-6-oxohexanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• InChI: InChI=1S/C49H71N7O14/c57-44(11-5-6-12-46(59)56-35-42-9-2-1-7-40(42)13-14-41-8-3-4-10-43(41)56)50-15-25-66-27-29-68-31-33-70-34-32-69-30-28-67-26-16-51-45(58)36-52-17-19-53(37-47(60)61)21-23-55(39-49(64)65)24-22-54(20-18-52)38-48(62)63/h1-4,7-10H,5-6,11-12,15-39H2,(H,50,57)(H,51,58)(H,60,61)(H,62,63)(H,64,65)
• InChIKey: KJESTZWHHDGJAU-UHFFFAOYSA-N
• SMILES: C1CN(CCN(CCN(CCN1CC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CCCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42)CC(=O)O)CC(=O)O)CC(=O)O

DOTA-PEG5-C6-DBCO（Cat No.:I026466）is a multifunctional reagent combining a DOTA chelator, a PEG5 spacer, a C6 alkyl linker, and a dibenzocyclooctyne (DBCO) group. The DOTA moiety serves as a versatile chelating agent for radiometals, enabling applications in molecular imaging, radiotherapy, and diagnostic probe development. The DBCO functionality allows rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azide-containing biomolecules, supporting efficient bioconjugation. The PEG5-C6 linker enhances solubility, imparts flexibility, and reduces steric hindrance, ensuring high reactivity and stability. This reagent is valuable for radiolabeling, targeted drug delivery, and bioorthogonal chemistry applications.