Domoic Acid

  • CAT Number: R056495
  • CAS Number: 14277-97-5
  • Molecular Formula: C15H21NO6
  • Molecular Weight: 311.33
  • Purity: ≥95%
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Domoic Acid(Cat No.: R056495) is a naturally occurring toxin produced by certain species of marine microalgae, such as Pseudo-nitzschia spp., and causes Amnesic Shellfish Poisoning (ASP) in humans and wildlife when consumed via contaminated shellfish or other seafood. Domoic acid is a potent neurotoxin that can cause damage to the brain and nervous system, leading to symptoms such as vomiting, diarrhea, confusion, seizures, and in severe cases, coma or death.

Catalog Number R056495
CAS Number 14277-97-5
Synonyms

(2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid; (-)-Domoic Acid; L-Domoic Acid; NSC 288031;

Molecular Formula

C15H21NO6

Purity 95%
Target Kainate Receptors
Solubility Soluble to 50 mM in sterile water
Storage Desiccate at -20°C
IUPAC Name (2S,3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid
InChI InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1
InChIKey VZFRNCSOCOPNDB-AOKDLOFSSA-N
SMILES CC(C=CC=C(C)C1CNC(C1CC(=O)O)C(=O)O)C(=O)O
Reference

<p>
<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.&nbsp;Hampson, David R., and Jerrie Lynn Manalo. &quot;The activation of glutamate receptors by kainic acid and domoic acid.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Natural toxins</i>&nbsp;6.3‐4 (1998): 153-158.<br />
2.Hampson, David R., et al. &quot;Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>European journal of pharmacology</i>&nbsp;218.1 (1992): 1-8.</span></span></span></p>

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