Dodecylphosphocholine-d38

• CAT Number: M118075
• CAS Number: 130890-78-7
• Molecular Formula: C17D38NO4P
• Molecular Weight: 389.70
• Purity: ≥95%
• Synonyms: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-pentacosadeuteriododecyl [1,1,2,2-tetradeuterio-2-[tris(trideuteriomethyl)azaniumyl]ethyl] phosphate
• InChI: InChI=1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3/i1D3,2D3,3D3,4D3,5D2,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2,16D2,17D2
• InChIKey: QBHFVMDLPTZDOI-DHIOKLJKSA-N
• SMILES: CCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C

Dodecylphosphocholine-d38 (Cat No.: 130890-78-7) is a fully deuterated analog of dodecylphosphocholine, a zwitterionic detergent commonly used in membrane protein structural biology. With 38 deuterium atoms incorporated, it is especially valuable for NMR spectroscopy and other biophysical studies requiring isotope-labeled detergents. DPC-d38 effectively solubilizes and stabilizes membrane proteins while minimizing background signals in spectroscopic assays. It is widely applied in research focused on protein–lipid interactions, micelle formation, and membrane protein folding, serving as a key tool in structural biology and biophysical chemistry.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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