DNA2 inhibitor C5

• CAT Number: I017951
• CAS Number: 35973-25-2
• Molecular Formula: C10H6N2O5
• Molecular Weight: 234.17
• Purity: ≥95%
• Synonyms: 8-nitro-4-oxo-1H-quinoline-3-carboxylic acid
• InChI: InChI=1S/C10H6N2O5/c13-9-5-2-1-3-7(12(16)17)8(5)11-4-6(9)10(14)15/h1-4H,(H,11,13)(H,14,15)
• InChIKey: BMIZBCVEHSUUNO-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C1)[N+](=O)[O-])NC=C(C2=O)C(=O)O

DNA2 inhibitor C5（Cat No.:I017951）is a small-molecule compound that selectively targets the DNA replication helicase/nuclease DNA2, a key enzyme involved in DNA replication, repair, and genomic stability. By inhibiting DNA2 activity, C5 disrupts homologous recombination repair and replication fork processing, leading to accumulation of DNA damage and reduced tumor cell survival. Preclinical studies suggest it sensitizes cancer cells to DNA-damaging agents, making it a potential adjuvant in chemotherapy. With its novel mechanism, DNA2 inhibitor C5 is a valuable research tool for exploring DNA repair pathways and developing anticancer strategies.