For research use only. Not for therapeutic Use.
DMT-dA(PAc) Phosphoramidite（Cat No.:M010049）is a protected deoxyadenosine building block used in automated DNA synthesis. It features a 4,4′-dimethoxytrityl (DMT) group protecting the 5′-hydroxyl, ensuring selective chain elongation, while the exocyclic amine of adenine is shielded with a phenoxyacetyl (PAc) group to maintain base integrity. The 3′-phosphoramidite moiety enables efficient coupling to growing oligonucleotide chains. This reagent offers high coupling efficiency and is ideal for synthesizing high-fidelity DNA sequences used in diagnostics, therapeutics, and molecular biology research where sequence accuracy and functional versatility are essential.
| CAS Number | 110543-74-3 |
| Synonyms | N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide |
| Molecular Formula | C48H54N7O8P |
| Purity | ≥95% |
| IUPAC Name | N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide |
| InChI | InChI=1S/C48H54N7O8P/c1-33(2)55(34(3)4)64(61-27-13-26-49)63-41-28-44(54-32-52-45-46(50-31-51-47(45)54)53-43(56)30-59-40-16-11-8-12-17-40)62-42(41)29-60-48(35-14-9-7-10-15-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,31-34,41-42,44H,13,27-30H2,1-6H3,(H,50,51,53,56)/t41-,42+,44+,64?/m0/s1 |
| InChIKey | INUFZOANRLMUCW-SDNJGBRXSA-N |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@@H](O[C@@H]1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=NC6=C(N=CN=C65)NC(=O)COC7=CC=CC=C7 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
