For research use only. Not for therapeutic Use.
DMH4（Cat No.:R057465）is a selective small-molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2 or KDR), a key mediator of angiogenesis. By blocking VEGFR2 signaling, DMH4 effectively inhibits endothelial cell proliferation, migration, and new blood vessel formation. It is widely used in developmental biology and cancer research to study vascular development, tumor angiogenesis, and anti-angiogenic therapeutic strategies. Unlike some pan-kinase inhibitors, DMH4 offers greater specificity for VEGFR2, making it a valuable tool for dissecting VEGF-driven pathways and evaluating the role of angiogenesis in various pathological conditions.
| CAS Number | 515880-75-8 |
| Synonyms | 4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine |
| Molecular Formula | C24H24N4O2 |
| Purity | ≥95% |
| IUPAC Name | 4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine |
| InChI | InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2 |
| InChIKey | SKZQZGSPYYHTQG-UHFFFAOYSA-N |
| SMILES | C1COCCN1CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=CC=C5)N=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
