For research use only. Not for therapeutic Use.
DM-01（Cat No.:I014943）is a small-molecule inhibitor that targets the MDM2–p53 interaction, a critical regulatory pathway in cancer biology. By blocking MDM2 binding, DM-01 stabilizes and activates p53, restoring its tumor-suppressive functions such as apoptosis induction and cell cycle arrest. This mechanism makes DM-01 a valuable tool for studying p53-dependent pathways and therapeutic strategies in oncology. Preclinical studies suggest potential applications in cancers with overexpressed MDM2 but functional p53. DM-01 is widely used in cancer research to explore targeted therapies and drug resistance mechanisms.
| CAS Number | 2355280-00-9 |
| Synonyms | N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,4-dimethyl-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrole-3-carboxamide |
| Molecular Formula | C23H24F3N3O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,4-dimethyl-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrole-3-carboxamide |
| InChI | InChI=1S/C23H24F3N3O2/c1-13-9-15(3)28-21(30)19(13)10-27-22(31)20-14(2)11-29(16(20)4)12-17-5-7-18(8-6-17)23(24,25)26/h5-9,11H,10,12H2,1-4H3,(H,27,31)(H,28,30) |
| InChIKey | XHYKDXOCUIJBHL-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C=C2C)CC3=CC=C(C=C3)C(F)(F)F)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
