For research use only. Not for therapeutic Use.
DLinDMA (Cat No.: I019811) is a cationic lipid used in the development of lipid nanoparticles (LNPs) for delivering nucleic acids such as siRNA and mRNA. It facilitates encapsulation, cellular uptake, and endosomal escape of genetic materials, enabling effective intracellular delivery. DLinDMA was instrumental in early RNA-based therapeutic research but has largely been replaced by more advanced lipids like DLin-MC3-DMA in clinical formulations. Despite this, DLinDMA remains widely used in preclinical studies for gene therapy and vaccine delivery applications.
| CAS Number | 871258-12-7 |
| Synonyms | N,N-dimethyl-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine |
| Molecular Formula | C41H77NO2 |
| Purity | ≥95% |
| IUPAC Name | N,N-dimethyl-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine |
| InChI | InChI=1S/C41H77NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-4H3/b15-13-,16-14-,21-19-,22-20- |
| InChIKey | NFQBIAXADRDUGK-KWXKLSQISA-N |
| SMILES | CCCCCC=CCC=CCCCCCCCCOCC(CN(C)C)OCCCCCCCCC=CCC=CCCCCC |
| Reference | [1]. Semple SC, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010 Feb;28(2):172-6. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
