For research use only. Not for therapeutic Use.
DKFZ-748 (Cat No.: I042605) is a potent and selective inhibitor of the histone acetyltransferase EP300/CBP, enzymes involved in chromatin remodeling and gene transcription regulation through lysine acetylation. By targeting the catalytic activity of EP300/CBP, DKFZ-748 modulates gene expression, particularly in oncogenic pathways dependent on these coactivators. It is a valuable research tool in studying epigenetic regulation, cancer biology, and potential therapeutic interventions. DKFZ-748 shows promise in preclinical models, especially for cancers with transcriptional addiction or EP300/CBP-related dysregulation.
| CAS Number | 2490709-68-5 |
| Synonyms | N-[2-[[4-(hydroxyamino)-4-oxobutyl]-methylamino]ethyl]naphthalene-1-carboxamide |
| Molecular Formula | C18H23N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H23N3O3/c1-21(12-5-10-17(22)20-24)13-11-19-18(23)16-9-4-7-14-6-2-3-8-15(14)16/h2-4,6-9,24H,5,10-13H2,1H3,(H,19,23)(H,20,22) |
| InChIKey | KLGDKBPAEMOECW-UHFFFAOYSA-N |
| SMILES | CN(CCCC(=O)NO)CCNC(=O)C1=CC=CC2=CC=CC=C21 |
| Reference | [1]. Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
