Dimethyl fluoromalonate

• CAT Number: L011170
• CAS Number: 344-14-9
• Molecular Formula: C5H7FO4
• Molecular Weight: 150.11
• Purity: ≥95%
• IUPAC Name: dimethyl 2-fluoropropanedioate
• InChI: InChI=1S/C5H7FO4/c1-9-4(7)3(6)5(8)10-2/h3H,1-2H3
• InChIKey: ZVXHZSXYHFBIEW-UHFFFAOYSA-N

Dimethyl fluoromalonate(CAT: L011170) is a fluorinated malonate ester featuring two methyl ester groups and a strategically positioned fluorine atom, offering unique reactivity for advanced organic synthesis. It is a key building block in the preparation of fluorinated pharmaceuticals, agrochemicals, and fine chemicals, where the fluorine atom can enhance bioavailability, metabolic stability, and target binding affinity. Its structure allows for facile enolate formation and alkylation, making it highly versatile in constructing carbon–carbon bonds and introducing fluorinated motifs. Dimethyl fluoromalonate is particularly valuable in medicinal chemistry programs focused on incorporating fluorine into drug candidates for improved pharmacokinetic and physicochemical properties.