Dimethyl (2-Oxopropyl)phosphonate

• CAT Number: R030699
• CAS Number: 4202-14-6
• Molecular Formula: C5H11O4P
• Molecular Weight: 166.11
• Purity: ≥95%
• Synonyms: (2-Oxopropyl)phosphonic Acid Dimethyl Ester; (Dimethylphosphono)acetone;?Dimethyl (2-oxopropyl)phosphonate; Dimethyl 2-oxopropanephosphonate?Dimethyl Acetonylphosphonate; Dimethyl β-keto-propylphosphonate?
• Storage: Store at -20°C
• IUPAC Name: 1-dimethoxyphosphorylpropan-2-one
• InChI: InChI=1S/C5H11O4P/c1-5(6)4-10(7,8-2)9-3/h4H2,1-3H3
• InChIKey: UOWIYNWMROWVDG-UHFFFAOYSA-N
• SMILES: CC(=O)CP(=O)(OC)OC

Dimethyl (2-oxopropyl)phosphonate（Cat No.:R030699）is an organophosphorus compound featuring a phosphonate ester group bonded to a 2-oxopropyl moiety. It is a versatile synthetic intermediate commonly used in organic and medicinal chemistry, particularly in the Horner–Wadsworth–Emmons (HWE) reaction for constructing α,β-unsaturated carbonyl compounds. The ketone functionality provides electrophilic reactivity, while the dimethyl phosphonate group enables nucleophilic attack under basic conditions. This dual reactivity makes it valuable for designing complex molecules such as pharmaceuticals, agrochemicals, and bioactive heterocycles, often aiding in the formation of carbon–carbon double bonds with high stereoselectivity.