Diketone-PEG4-PFP ester

• CAT Number: I016154
• CAS Number: 2353409-84-2
• Molecular Formula: C30H34F5NO9
• Molecular Weight: 647.58
• Purity: ≥95%
• Synonyms: (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[3-[4-(3,5-dioxohexyl)anilino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C30H34F5NO9/c1-19(37)18-22(38)7-4-20-2-5-21(6-3-20)36-23(39)8-10-41-12-14-43-16-17-44-15-13-42-11-9-24(40)45-30-28(34)26(32)25(31)27(33)29(30)35/h2-3,5-6H,4,7-18H2,1H3,(H,36,39)
• InChIKey: YJNZZHGXYBSDRO-UHFFFAOYSA-N
• SMILES: CC(=O)CC(=O)CCC1=CC=C(C=C1)NC(=O)CCOCCOCCOCCOCCC(=O)OC2=C(C(=C(C(=C2F)F)F)F)F

Diketone-PEG4-PFP ester（Cat No.:I016154）is a reactive PEG-based linker designed for selective and efficient bioconjugation. It features a diketone moiety suitable for chemoselective ligation, such as oxime or hydrazone bond formation with aminooxy or hydrazide groups, enabling site-specific modifications. The activated pentafluorophenyl (PFP) ester reacts efficiently with primary amines, forming stable amide bonds. The PEG4 spacer improves water solubility, provides flexibility, and minimizes steric hindrance in complex systems. This reagent is particularly useful for multifunctional conjugate synthesis, drug delivery, diagnostic probe development, and advanced chemical biology applications requiring orthogonal reactivity.