Diketone-PEG4-Biotin

• CAT Number: I015987
• CAS Number: 2353409-85-3
• Molecular Formula: C33H50N4O9S
• Molecular Weight: 678.84
• Purity: ≥95%
• Synonyms: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[3-[4-(3,5-dioxohexyl)anilino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C33H50N4O9S/c1-24(38)22-27(39)11-8-25-6-9-26(10-7-25)35-31(41)12-14-43-16-18-45-20-21-46-19-17-44-15-13-34-30(40)5-3-2-4-29-32-28(23-47-29)36-33(42)37-32/h6-7,9-10,28-29,32H,2-5,8,11-23H2,1H3,(H,34,40)(H,35,41)(H2,36,37,42)/t28-,29-,32-/m0/s1
• InChIKey: CJUCDLZQRUQWCG-OLWNVYNHSA-N
• SMILES: CC(=O)CC(=O)CCC1=CC=C(C=C1)NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3

Diketone-PEG4-Biotin（Cat No.:I015987）is a functional biotinylation reagent composed of a biotin moiety linked through a four-unit PEG spacer to a reactive diketone group. The PEG4 chain enhances solubility, flexibility, and minimizes steric hindrance, improving accessibility in biomolecular interactions. The diketone group provides a versatile reactive handle for chemoselective conjugation, enabling stable linkage with nucleophiles such as hydrazines or aminooxy groups. This reagent is widely used in bioconjugation, protein labeling, and drug discovery, where it facilitates targeted binding, affinity purification, and the development of multifunctional biomolecular probes or therapeutic constructs.