Dihydrowithaferin A

• CAT Number: I017924
• CAS Number: 5589-41-3
• Molecular Formula: C28H40O6
• Molecular Weight: 472.61
• Purity: ≥95%
• Synonyms: (1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-3-one
• IUPAC Name: 6-hydroxy-15-[1-[5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-3-one
• InChI: InChI=1S/C28H40O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h15-16,18-21,23-24,29,31H,5-13H2,1-4H3
• InChIKey: YRXCLNDPESBJHL-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)CCC6O)C)O5)C)CO

Dihydrowithaferin A（Cat No.:I017924）is a natural withanolide derivative isolated from Withania somnifera (Ashwagandha), a medicinal plant used in Ayurveda. It retains structural similarity to withaferin A but differs by hydrogenation, offering distinct pharmacological properties. Dihydrowithaferin A exhibits anti-inflammatory, anticancer, and antioxidant activities by modulating pathways such as NF-κB, apoptosis, and oxidative stress responses. Preclinical studies suggest potential in suppressing tumor growth, reducing inflammation, and protecting against cellular damage. As a bioactive steroidal lactone, dihydrowithaferin A provides a promising lead compound for cancer, immunology, and neuroprotection research.