Dihexa(CAT: R029524) is an oligopeptide derived from angiotensin Ⅳ. It has a high affinity with hepatocyte growth factor and therefore has good binding activity to the C-Met receptor. Currently, it is mainly used in the research of adjunctive therapy for Alzheimer’s disease. This product is used for medical research and development and other scientific research purposes.
| Catalog Number | R029524 |
| CAS Number | 1401708-83-5 |
| Synonyms | N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide |
| Molecular Formula | C27 H44 N4 O5 |
| Purity | 95% |
| Storage | Desiccate at +4C |
| IUPAC Name | (2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide |
| InChI | InChI=1S/C27H44N4O5/c1-4-6-8-12-24(34)30-22(18-20-13-15-21(32)16-14-20)26(35)31-25(19(3)5-2)27(36)29-17-10-7-9-11-23(28)33/h13-16,19,22,25,32H,4-12,17-18H2,1-3H3,(H2,28,33)(H,29,36)(H,30,34)(H,31,35)/t19-,22-,25-/m0/s1 |
| InChIKey | XEUVNVNAVKZSPT-JTJYXVOQSA-N |
| SMILES | O=C(N)CCCCCNC([C@@H](NC([C@@H](NC(CCCCC)=O)CC1=CC=C(O)C=C1)=O)[C@@H](C)CC)=O |
| Reference | 1. Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402.<br /> |
