Dihexa

• CAT Number: R029524
• CAS Number: 1401708-83-5
• Molecular Formula: C27 H44 N4 O5
• Molecular Weight: 504.66
• Purity: ≥95%
• Storage: Desiccate at +4C
• IUPAC Name: (2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide
• InChI: InChI=1S/C27H44N4O5/c1-4-6-8-12-24(34)30-22(18-20-13-15-21(32)16-14-20)26(35)31-25(19(3)5-2)27(36)29-17-10-7-9-11-23(28)33/h13-16,19,22,25,32H,4-12,17-18H2,1-3H3,(H2,28,33)(H,29,36)(H,30,34)(H,31,35)/t19-,22-,25-/m0/s1
• InChIKey: XEUVNVNAVKZSPT-JTJYXVOQSA-N
• SMILES: O=C(N)CCCCCNC([C@@H](NC([C@@H](NC(CCCCC)=O)CC1=CC=C(O)C=C1)=O)[C@@H](C)CC)=O

Dihexa(CAT: R029524) is an oligopeptide derived from angiotensin Ⅳ. It has a high affinity with hepatocyte growth factor and therefore has good binding activity to the C-Met receptor. Currently, it is mainly used in the research of adjunctive therapy for Alzheimer’s disease. This product is used for medical research and development and other scientific research purposes.

Reference

1. Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402.
2. McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54.