Diethyl p-Toluenesulfonyloxymethylphosphonate

• CAT Number: R003473
• CAS Number: 31618-90-3
• Molecular Formula: C12H19O6PS
• Molecular Weight: 322.31
• Purity: ≥95%
• Synonyms: P-[[[(4-Methylphenyl)sulfonyl]oxy]methyl]phosphonic Acid Diethyl Ester; Tosyloxymethyl Diethyl Phosphonate; [[[(4-Tolyl)sulfonyl]oxy]methyl]phosphonic Acid Diethyl Ester
• Storage: -20°C
• IUPAC Name: diethoxyphosphorylmethyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3
• InChIKey: UOEFFQWLRUBDME-UHFFFAOYSA-N
• SMILES: CCOP(=O)(COS(=O)(=O)C1=CC=C(C=C1)C)OCC

Diethyl p-toluenesulfonyloxymethylphosphonate (Cat No.: R003473) is an organophosphorus compound used as a versatile intermediate in organic synthesis, particularly in the preparation of nucleotides and antiviral agents. It features a phosphonate group and a tosylated oxymethyl moiety, making it reactive in nucleophilic substitution and phosphorylation reactions. The p-toluenesulfonyl (tosyl) group acts as a good leaving group, facilitating selective transformations. Its utility in introducing phosphonate functionality into biologically active molecules makes it valuable in medicinal chemistry and the development of phosphonate-based therapeutics.