Diethyl Bromodifluoromethylphosphonate

• CAT Number: R025650
• CAS Number: 65094-22-6
• Molecular Formula: C5H10BrF2O3P
• Molecular Weight: 267.01
• Purity: ≥95%
• Synonyms: P-(Bromodifluoromethyl)phosphonic Acid Diethyl Ester; (Bromodifluoromethyl)phosphonic Acid Diethyl Ester
• Storage: 2°C to 8°C
• IUPAC Name: 1-[[bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane
• InChI: InChI=1S/C5H10BrF2O3P/c1-3-10-12(9,11-4-2)5(6,7)8/h3-4H2,1-2H3
• InChIKey: QRADKVYIJIAENZ-UHFFFAOYSA-N
• SMILES: CCOP(=O)(C(F)(F)Br)OCC

Diethyl bromodifluoromethylphosphonate（Cat No.:R025650）is an organophosphorus compound characterized by a bromodifluoromethyl group bonded to a phosphonate ester moiety with two ethyl groups. It is a reactive intermediate commonly used in fluorine chemistry and the synthesis of bioactive molecules. The bromodifluoromethyl group serves as a versatile electrophile, enabling incorporation of the difluoromethylphosphonate unit into a wide range of substrates. This compound is valuable in medicinal chemistry for introducing metabolically stable fluorinated phosphonate analogs, which can mimic phosphate esters or carboxylic acids in drug design, particularly in enzyme inhibitor and prodrug development.