Diethyl 2-Acetamidomalonate

• CAT Number: R021760
• CAS Number: 1068-90-2
• Molecular Formula: C9H15NO5
• Molecular Weight: 217.22
• Purity: ≥95%
• Synonyms: 2-(Acetylamino)propanedioic Acid 1,3-Diethyl Ester; Acetamidomalonic Acid Diethyl Ester; (Acetylamino)malonic Acid Diethyl Ester; 2-Acetylamino-malonic Acid Diethyl Ester; Diethyl (N-Acetylamino)malonate; Diethyl (Acetylamino)malonate; Diethyl 2-Acet
• Storage: -20°C
• IUPAC Name: diethyl 2-acetamidopropanedioate
• InChI: InChI=1S/C9H15NO5/c1-4-14-8(12)7(10-6(3)11)9(13)15-5-2/h7H,4-5H2,1-3H3,(H,10,11)
• InChIKey: ISOLMABRZPQKOV-UHFFFAOYSA-N
• SMILES: CCOC(=O)C(C(=O)OCC)NC(=O)C

Diethyl 2-Acetamidomalonate(CAT: R021760) is an important intermediate in organic synthesis with the molecular formula C₉H₁₅NO₅. Structurally, it features a malonate backbone esterified with two ethyl groups and substituted with an acetamido functional group at the α-position. This versatile compound is commonly used in the synthesis of α-amino acids, peptides, and heterocyclic compounds. Its reactive methylene group allows for nucleophilic substitution and condensation reactions, making it a valuable building block in pharmaceutical and agrochemical research. Diethyl 2-Acetamidomalonate is typically supplied as a colorless to pale yellow liquid or crystalline solid, soluble in common organic solvents like ethanol and acetone.