Diclofenac Diethylamine- CAS 78213-16-8

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Catalog Number: A000508

CAS Number: 78213-16-8

PubChem Substance ID:355039370

Molecular Formula: C14H11Cl2NO2.C4H11N

Molecular Weight:369.29

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: NA

Property

• Molecular Formula: C14H11Cl2NO2.C4H11N
• Molecular Weight: 369.29
• Purity: ≥95%
• Storage: 3 years -20C powder