Diazo Biotin-PEG3-alkyne

• CAT Number: I014328
• CAS Number: 1884349-58-9
• Molecular Formula: C39H53N7O9S
• Molecular Weight: 795.95
• Purity: ≥95%
• Synonyms: Diazo Biotin-PEG3-alkyne;4-(2-(2-hydroxy-5-(2-(3-(prop-2-yn-1-yloxy)propanamido)ethyl)phenyl)-1l2,2l2-diazanyl)-N-(13-oxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)benzamide
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C39H53N7O9S/c1-2-18-52-19-14-36(49)40-15-13-28-7-12-33(47)31(26-28)46-45-30-10-8-29(9-11-30)38(50)42-17-21-54-23-25-55-24-22-53-20-16-41-35(48)6-4-3-5-34-37-32(27-56-34)43-39(51)44-37/h1,7-12,26,32,34,37,47H,3-6,13-25,27H2,(H,40,49)(H,41,48)(H,42,50)(H2,43,44,51)/t32-,34-,37-/m0/s1
• InChIKey: AIUZFZDETVBCLH-OHTDSXDOSA-N
• SMILES: O=C1N[C@@]2([H])CS[C@@H](CCCCC(NCCOCCOCCOCCNC(C3=CC=C([N][N]C4=CC(CCNC(CCOCC#C)=O)=CC=C4O)C=C3)=O)=O)[C@@]2([H])N1

Diazo Biotin-PEG3-alkyne (Cat No.: I014328) is a multifunctional chemical probe featuring a diazo group, a biotin moiety, and a PEG3-alkyne linker. It is designed for bioorthogonal labeling and enrichment applications, particularly in click chemistry and proteomics. The alkyne group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the biotin tag allows affinity purification using streptavidin-based systems. The PEG3 spacer enhances solubility and reduces steric hindrance. Diazo Biotin-PEG3-alkyne is widely used for protein labeling, target identification, and studying biomolecular interactions in complex biological systems.

Reference

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