Diapamide

• CAT Number: I006476
• CAS Number: 3688-85-5
• Molecular Formula: C9H11ClN2O3S
• Molecular Weight: 262.71
• Purity: ≥95%
• Synonyms: Diapamide ; CN-36,337; CN-36337; D 1593; D-1593; Diapamide; NSC 178204; Thiamizide; Tiamizid; Tiamizida.;4-Chloro-N-methyl-3-((methylamino)sulfonyl)benzamide
• Solubility: Soluble in DMSO, not in water
• Storage: Store at RT
• IUPAC Name: 4-chloro-N-methyl-3-(methylsulfamoyl)benzamide
• InChI: InChI=1S/C9H11ClN2O3S/c1-11-9(13)6-3-4-7(10)8(5-6)16(14,15)12-2/h3-5,12H,1-2H3,(H,11,13)
• InChIKey: REQFWARMBJWJAQ-UHFFFAOYSA-N
• SMILES: CNC(=O)C1=CC(=C(C=C1)Cl)S(=O)(=O)NC

Diapamide (Cat No.: I006476) is a sulfonamide-derived diuretic with antihypertensive properties, structurally related to thiazide diuretics. It acts primarily on the distal convoluted tubules of the kidney to inhibit sodium and chloride reabsorption, promoting diuresis and reducing blood volume, which helps lower blood pressure. Diapamide may also exhibit mild vasodilatory effects, contributing to its antihypertensive action. It is used in the management of hypertension and fluid retention disorders. Common side effects may include electrolyte imbalance, dizziness, increased urination, and gastrointestinal discomfort.

Reference

1:J Clin Pharmacol. 1979 Feb-Mar;19(2-3):127-36. Evaluation of a new diuretic, diapamide, in congestive heart failure.Coodley EL,Nandi PS,Chiotellis P, PMID: 370157 Abstract: The diuretic response of patients with congestive heart failure to establish doses of diapamide (750 mg) and furosemide (80 mg) was compared in an open, crossover study. Peak urine output occurred in the first 6 hours after administration of furosemide but somewhat later (12 to 18 hours) with diapamide. Both agents produced active diuresis and natriuresis in most patients. Comparisons of drug effect during the first days of each treatment period and analysis of the entire first treatment period indicated that urine output with furosemide was significantly greater than with diapamide. Urinary sodium excretion on the first day of treatment was not significantly greater with furosemide than with diapamide, nor were the differences significant on subsequent days. The observed differences between drugs on urinary potassium and chloride excretion were not statistically significant. The most frequently occurring adverse reaction was mild to moderate nausea, which was reported by five patients receiving diapamide and two patients receiving furosemide. Diarrhea and vomiting were also more frequent with diapamide. Diapamide would appear to serve a role between the milder thiazide diuretics and the more effective furosemide.