For research use only. Not for therapeutic Use.
Dianicline dihydrochloride (Cat No.:I006475) is a selective partial agonist of neuronal nicotinic acetylcholine receptors (nAChRs), primarily targeting the α4β2 subtype. It was developed as a potential smoking cessation aid, aiming to reduce nicotine craving and withdrawal symptoms while providing partial receptor activation to ease dependence. Preclinical and clinical studies showed that dianicline could attenuate nicotine’s reinforcing effects and support abstinence. Although it demonstrated promise, its clinical development was discontinued due to limited efficacy compared with existing therapies. It remains valuable in neuropharmacology research on addiction mechanisms.
| CAS Number | 292634-27-6 |
| Molecular Formula | C13H18Cl2N2O |
| Purity | ≥95% |
| IUPAC Name | (1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.01,10.03,8]hexadeca-3(8),4,6-triene |
| InChI | InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1 |
| InChIKey | SUPRUPHAEXPGPF-QWHCGFSZSA-N |
| SMILES | C1CN2CC[C@@]3(C2)[C@H]1OC4=C(C3)N=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
