Di-tert-butyl Chloromethyl Phosphate

• CAT Number: L012178
• CAS Number: 229625-50-7
• Molecular Formula: C9H20ClO4P
• Molecular Weight: 258.68
• Purity: ≥95%
• IUPAC Name: ditert-butyl chloromethyl phosphate
• InChI: InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3
• InChIKey: LNJAJHJFSKUCIR-UHFFFAOYSA-N
• SMILES: CC(C)(C)OP(=O)(OCCl)OC(C)(C)C

Di-tert-butyl chloromethyl phosphate（Cat No.:L012178）is an organophosphorus compound with the formula C9H20ClO4P. It features a chloromethyl group (–CH₂Cl) attached to a phosphate core, which is further protected by two bulky tert-butyl ester groups. This compound is commonly used as a phosphorylating reagent in organic synthesis, particularly for introducing phosphate groups under mild conditions. Its steric bulk offers selective reactivity and stability during multi-step synthetic procedures, especially in nucleotide or prodrug chemistry. It is typically a colorless to pale yellow liquid and should be handled under inert atmosphere due to moisture sensitivity and potential reactivity.