Di-O-methyldemethoxycurcumin

• CAT Number: I017280
• CAS Number: 824951-60-2
• Molecular Formula: C22H22O5
• Molecular Weight: 366.41
• Purity: ≥95%
• Synonyms: (1E,6E)-1-(3,4-dimethoxyphenyl)-7-(4-methoxyphenyl)hepta-1,6-diene-3,5-dione
• InChI: InChI=1S/C22H22O5/c1-25-20-11-6-16(7-12-20)4-9-18(23)15-19(24)10-5-17-8-13-21(26-2)22(14-17)27-3/h4-14H,15H2,1-3H3/b9-4+,10-5+
• InChIKey: FTMVHEMEBLBNPN-LUZURFALSA-N
• SMILES: COC1=CC=C(C=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)OC)OC

Di-O-methyldemethoxycurcumin(CAT: I017280) is a naturally derived curcumin analog belonging to the diarylheptanoid class of polyphenols. As a structural derivative of curcumin, it exhibits improved stability and bioavailability while retaining strong antioxidant, anti-inflammatory, and anticancer activities. Studies demonstrate that Di-O-methyldemethoxycurcumin modulates key signaling pathways such as NF-κB, MAPK, and apoptotic cascades, contributing to its cytoprotective and antiproliferative effects. It has shown potential in inhibiting tumor growth, reducing oxidative stress, and regulating inflammatory responses. With its enhanced pharmacological profile compared to native curcumin, Di-O-methyldemethoxycurcumin serves as a valuable research tool in cancer, metabolic disease, and neurodegenerative disorder studies.