DI-82

• CAT Number: I015186
• CAS Number: 1638148-50-1
• Molecular Formula: C20H26N6O4S3
• Molecular Weight: 510.65
• Purity: ≥95%
• Synonyms: N-[2-[5-[4-[(1R)-1-(4,6-diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
• InChI: InChI=1S/C20H26N6O4S3/c1-11-18(12(2)32-20-24-16(21)10-17(22)25-20)26-19(31-11)13-5-6-14(29-3)15(9-13)30-8-7-23-33(4,27)28/h5-6,9-10,12,23H,7-8H2,1-4H3,(H4,21,22,24,25)/t12-/m1/s1
• InChIKey: MBPWFMBRNJJXFY-GFCCVEGCSA-N
• SMILES: CC1=C(N=C(S1)C2=CC(=C(C=C2)OC)OCCNS(=O)(=O)C)[C@@H](C)SC3=NC(=CC(=N3)N)N

DI-82（Cat No.:I015186）is a potent and selective small-molecule inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme in the de novo pyrimidine biosynthesis pathway. By blocking DHODH activity, DI-82 effectively reduces pyrimidine availability, suppressing DNA/RNA synthesis and cell proliferation. This mechanism makes it highly valuable for studying cancer metabolism, immune regulation, and antiviral strategies. Research highlights its potential in leukemia, autoimmune disorders, and viral infection models. DI-82 serves as a powerful chemical probe for investigating DHODH-related signaling and therapeutic interventions.