DHX9-IN-2

• CAT Number: I040542
• CAS Number: 2973395-71-8
• Molecular Formula: C18H16ClN3O3S2
• Molecular Weight: 421.92
• Purity: ≥95%
• Synonyms: N-[3-chloro-5-(methanesulfonamido)phenyl]-4-(3-methylpyridin-2-yl)thiophene-2-carboxamide
• InChI: InChI=1S/C18H16ClN3O3S2/c1-11-4-3-5-20-17(11)12-6-16(26-10-12)18(23)21-14-7-13(19)8-15(9-14)22-27(2,24)25/h3-10,22H,1-2H3,(H,21,23)
• InChIKey: VDGNPEFFHQRGOP-UHFFFAOYSA-N
• SMILES: CC1=C(N=CC=C1)C2=CSC(=C2)C(=O)NC3=CC(=CC(=C3)Cl)NS(=O)(=O)C

DHX9-IN-2(CAT: I040542) is a potent and selective small-molecule inhibitor targeting the RNA helicase DHX9, a key regulator of RNA metabolism and genome stability. By interfering with DHX9’s helicase activity, DHX9-IN-2 disrupts DNA-RNA hybrid resolution, influencing gene expression and replication stress responses. This compound is valuable for studying transcriptional regulation, DNA damage repair, and cancer biology, especially in tumors with high DHX9 expression. DHX9-IN-2 offers a promising tool for dissecting helicase-related pathways and exploring therapeutic strategies targeting R-loop dynamics in oncology and genome instability-related disorders. Ideal for in vitro applications requiring modulation of DHX9 activity in molecular and cellular studies.