DHX9-IN-1

• CAT Number: I040543
• CAS Number: 2973747-89-4
• Molecular Formula: C21H21F2N5O3S
• Molecular Weight: 461.48
• Purity: ≥95%
• Synonyms: 5-[5-(3,3-difluoroazetidin-1-yl)pyridin-2-yl]-N-[3-(methanesulfonamido)phenyl]-1-methylpyrrole-3-carboxamide
• InChI: InChI=1S/C21H21F2N5O3S/c1-27-11-14(20(29)25-15-4-3-5-16(9-15)26-32(2,30)31)8-19(27)18-7-6-17(10-24-18)28-12-21(22,23)13-28/h3-11,26H,12-13H2,1-2H3,(H,25,29)
• InChIKey: NFDWKTIXFFIEAC-UHFFFAOYSA-N
• SMILES: CN1C=C(C=C1C2=NC=C(C=C2)N3CC(C3)(F)F)C(=O)NC4=CC(=CC=C4)NS(=O)(=O)C

DHX9-IN-1 (CAT: I040543) is a potent small-molecule inhibitor targeting ATP-dependent RNA helicase A (DHX9), exhibiting an IC₅₀ of 9.45 nM. By selectively blocking DHX9 activity, it disrupts critical RNA processing and transcriptional regulation pathways involved in tumor growth and survival. This compound demonstrates significant antitumor potential, making it valuable for cancer biology research, particularly in studies of RNA metabolism, gene expression control, and helicase-related oncogenic signaling. DHX9-IN-1 is ideal for investigating the therapeutic targeting of RNA helicases and exploring novel mechanisms in cancer cell proliferation and apoptosis. Supplied in high purity for advanced biomedical research applications.